The Flashing Images above are designed to provide a "Mental Image" of what takes place when your brain's Pleasure Pathway is stimulated by activities associated with feeling good. Science now believes positive stimulation of your built in reward system can add many quality years to your life. Few activities stimulate our pleasure pathway more than Sexual Intercourse..........
Science has concluded our Pleasure Pathway plays a much greater role in our lives than just the survival of the species. It is now believed this Reward System has to be sufficiently stimulated as often as daily, if we are to feel, function and perform to our maximum potential. We don't have to become "Thrill Seekers" to stimulate our Reward System. Even the wise use of the basic necessities of life, such as eating, drinking and physical exercise stimulate our "Pleasure Pathway." But staying sexually active has its own set of rewards because you receive so many benefits from one activity. According to recent studies frequent orgasms, at least 100 per year, can increase Life Expectancy by 3 to 8 years.
Regular sexual activity is so beneficial to our health it is amazing how seldom it is discussed within this context. It lowers blood pressure, improves cholesterol, and increases circulation. It raises the heartbeat from 70 to 150 beats per minute. Some studies have found that people who indulge in regular sex are half as likely to have heart attacks and strokes than those who don't have sex at all. Every muscle in the body is worked and toned during sex, particularly the pelvis, buttocks, stomach and arms. Thirty minutes of sex can burn as many as 200 calories. There is substantial evidence it reduces food cravings, helps control your appetite and assists your body in absorbing the nutrients from food more easily. It boosts immunity, aids in tissue repair, increases cognition, reduces stress, improves sleep, promotes strong bones and one study found that regular orgasms even dramatically reduces the incidence of the common cold.
The intimacy and bonding you receive from remaining sexually active are more vital to your long term health than most people think. If you want to live a long and healthy life your biggest enemies are loneliness and boredom. Touch is necessary for all mammals to thrive, babies and animals that are deprived of physical touch rarely develop normally. Frequent touching is one way we enhance each others self esteem and nothing will help you live longer than a strong and vital sense of self worth. Tom LeDuc
Certain medical conditions can cause ED, including hypertension, diabetes, high cholesterol, coronary artery disease and peripheral artery disease. According to Dr. Foster, these disease processes can damage blood vessels in the penis.
And that’s a problem because erections are a vascular process. Here is how it works: When a man is sexually stimulated, the smooth muscle located inside blood vessels should relax, or dilate. This allows blood to flow into the corpora cavernosa, which are cylinder-shaped erectile bodies in the penis. The result is an erection. As blood continues to flow into the penis, its veins gradually constrict to form a “seal,” which helps to maintain the erection. Problems in achieving or maintaining an erection are often caused by insufficient blood flow into the penis or by a venous “leak,” which occurs when blood flows into the penis but then seeps out.
Other reasons for ED can include smoking, taking certain prescription antihypertensive or antidepressant medications, prostate removal surgery or nerve damage from a spinal cord injury. Low testosterone can affect sexual interest or libido, but it may also affect erection quality.
For younger men who don’t have other health conditions, ED can be caused by stress. “We know stress can inhibit erectile function,” says Dr. Martin J. Maassen. “Stress or anxiety, which releases adrenaline, constricts blood vessels.” And that means the erectile bodies won’t fill with enough blood.
Doctors often prescribe oral medications (phosphodiesterase type 5 inhibitors) as the first-line treatment for ED. Viagra (sildenafil), Levitra (vardenafil), Stendra (avanafil) and Cialis (tadalafil) work within 30 to 60 minutes and their effects last for between 4 and 8 hours (for Viagra, Levitra and Stendra) or 36 hours (for Cialis). These medications act as a smooth muscle relaxant, allowing increased blood flow to the penis when a man is sexually stimulated.
Although oral ED medications are estimated help 70 percent of men who try them, some may require a stronger dose of medication than is available orally.
charge in guanidinium group of L-Arginine
The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a guanidinium group, which has a pka of 12.48, and is therefore always protonated and positively charged at physiological pH. Because of the conjugation between the double bond and the nitrogen lone pairs, the positive charge is delocalized, enabling the formation of multiple hydrogen bonds
Growth hormone Intravenously administered arginine is used in growth hormone stimulation test because it stimulates the secretion of growth hormone.
High blood pressure A meta-analysis showed that L-arginine reduces blood pressure with pooled estimates of 5.4 mmHg for systolic blood pressure and 2.7 mmHg for diastolic blood pressure
Introduction: The efficacy and safety of arginine supplements in erectile dysfunction (ED)
Aim: To assess the potential role of arginine supplements on ED as alternatives to phosphodiesterase inhibitors.
Methods: Studies published up to April 2018 that evaluated the efficacy of arginine supplements were identified from multiple databases (Google Scholar, PubMed, Medline, Embase, Kiss, DBpia, and Cochrane databases). Studies comparing arginine supplements with placebo or no treatment; focusing only on patients with mild to moderate severity of ED; and presenting outcomes such as improvement rate, International Index of Erectile Function (IIEF) score, and adverse effects were included. Subgroup analysis for arginine alone and arginine in combination with other substances was further conducted to increase interpretability.
Main outcome measure: The strength of the association between arginine supplements and ED was assessed using relative odds ratios and weighted mean differences with 95% CI.
Results: In total, 10 randomized controlled trials met the inclusion criteria, reporting the outcomes of 540 patients with ED. The analysis demonstrated that arginine supplements with dosage ranging from 1,500 to 5,000 mg significantly improved ED compared with placebo or no treatment (odds ratios, 3.37 [1.29, 8.77], P = .01, I2 = 44). Arginine supplements also caused significant improvements in the IIEF subdomain scores of overall satisfaction, intercourse satisfaction, orgasmic function, and erectile function, whereas the IIEF sexual desire score remain unchanged. The adverse effect rate in the arginine-treated group was 8.3%, and that in the placebo group was 2.3%, none of which were severe.
Clinical implications: Arginine supplements can be recommended to patients with mild to moderate ED. Strength & limitations: The strength of this study is that it is the first meta-analysis to assess the potential role of arginine supplements in ED compared with placebo or no treatment. A limitation is that the treatment dosage and duration varied among studies, which may have contributed to study heterogeneity.
Conclusion: The results of our systematic review and meta-analysis provide evidence on the effectiveness of arginine supplements for mild to moderate ED. Rhim HC, Kim MS, Park Y-J, et al. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. J Sex Med 2019;16:223-234.